Whenever someone posts a question about towing in overdrive, the RV.net forum thread always gets a lot of different comments. We posted this question ourselves and our thanks go out to belairbrian who gave us the link to the definitive source for our F350, the Ford website.
Here is the link that brian gave us: Ford RV Trailering TIPS
The important quote appears in the center column at the very bottom of the page.
NOTE: With TorqShift transmissions, select Tow/Haul mode to automatically eliminate unwanted gear search and help control vehicle speed when going downhill.